TOPIC: Stimulating Subcortical Arousal Circuits to Induce Reanimation from General Anesthesia
TITLES AND INSTITUTION:
- Associate Professor of Anaesthesia, Harvard Medical School
- Department of Anesthesia, Critical Care and Pain Medicine
Massachusetts General Hospital
BIOGRAPHY AND AREAS OF RESEARCH:
Ken Solt is an attending anesthesiologist at Massachusetts General Hospital, and Associate Professor of Anaesthesia at Harvard Medical School in Boston, Massachusetts. He received the NIH Director’s Transformative Research Award in 2012, and the James S. McDonnell Foundation Scholar Award in Understanding Human Cognition in 2014. Solt uses a systems neuroscience approach to study the role of subcortical arousal circuits in emergence from general anesthesia. In the laboratory he combines neural circuit manipulations, neurophysiological recordings, and cognitive testing in rodents to induce reanimation, or active emergence from general anesthesia. He is also conducting clinical trials in surgical patients to test the efficacy of dopaminergic stimulants for accelerating emergence, reducing delirium, and improving post-operative cognitive function. His long-term goal is to elucidate the neural mechanisms of emergence from general anesthesia, and to develop therapeutic options for common clinical problems such as delayed emergence and post-operative delirium.
SELECTION OF PUBLICATIONS: